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<i>Diospyros nigra<_i> (J.F.Gmel.) M.R.Almeida

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Dopamine Receptor (3) Endogenous Metabolite (3) Ferroptosis (3) Fluorescent Dye (6) HIF/HIF Prolyl-Hydroxylase (1) Isotope-Labeled Compounds (1) Mitochondrial Metabolism (2) nAChR (1) Sirtuin (1) Tyrosinase (3) VEGFR (1) α-synuclein (2)
By Research Areas:	Cancer (2) Inflammation/Immunology (1) Metabolic Disease (2) Neurological Disease (9)

Inhibitors & Agonists

Screening Libraries

Biochemical Assay Reagents

Natural
Products

Isotope-Labeled Compounds

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-NP080

*Sambucus Nigra* Lectin** SNA	Fluorescent Dye	Others
Sambucus Nigra Lectin (SNA) is a plant lectin that can be used as a probe to specifically bind biomolecules (such as polysaccharides, peptides, etc.).Sambucus Nigra Lectin (SNA) is a biological material or organic compound that can be used in life science research .

HY-121227

Cylindrin	Others	Others
Cylindrin is a natural product that can be found in Diospyros nigra .

HY-NP0166

*Sambucus Nigra* Lectin (Agarose)**	Fluorescent Dye	Others
Sambucus Nigra Lectin (Agarose) is a plant lectin that can be used as a probe to specifically bind biomolecules (such as polysaccharides, peptides, etc.).Sambucus Nigra Lectin (Agarose) is a biological material or organic compound that can be used in life science research .

HY-NP0142

*Sambucus Nigra* Lectin (Fluorescein)** SNA (Fluorescein)	Fluorescent Dye	Others
Sambucus Nigra Lectin (SNA) Fluorescein is a plant lectin that can be used as a probe to specifically bind biomolecules (such as polysaccharides, peptides, etc.).Sambucus Nigra Lectin (SNA) Fluorescein is a biological material or organic compound that can be used in life science research .

HY-NP0149

*Sambucus Nigra* Lectin (Biotinylated)** SNA (Biotinylated)	Fluorescent Dye	Others
Sambucus Nigra Lectin (SNA) Biotinylated is a plant lectin that can be used as a probe to specifically bind biomolecules (such as polysaccharides, peptides, etc.).Sambucus Nigra Lectin (SNA) Biotinylated is a biological material or organic compound that can be used in life science research .

HY-NP092

*Sambucus Nigra* Lectin (CY3)** SNA (CY3)	Fluorescent Dye	Others
Sambucus Nigra Lectin (SNA) CY3 is a plant lectin that can be used as a probe to specifically bind biomolecules (such as polysaccharides, peptides, etc.).Sambucus Nigra Lectin (SNA) CY3 is a biological material or organic compound that can be used in life science research .

HY-NP094

*Sambucus Nigra* Lectin (CY5)** SNA (CY5)	Fluorescent Dye	Others
Sambucus Nigra Lectin (SNA) CY5 is a plant lectin that can be used as a probe to specifically bind biomolecules (such as polysaccharides, peptides, etc.).Sambucus Nigra Lectin (SNA) CY5 is a biological material or organic compound that can be used in life science research .

HY-N12541

Morunigrol C	Others	Inflammation/Immunology
Morunigrol C is a compound that can be isolated from the barks of Morus nigra .

HY-N12810

Sanggenon O	Tyrosinase	Others
Sanggenon O is a mushroom tyrosinase inhibitor that can be isolated from Morus nigra, with an IC₅₀ value of 1.15 μM .

HY-N10330

7-Hydroxyneolamellarin A	HIF/HIF Prolyl-Hydroxylase VEGFR	Cancer
7-Hydroxyneolamellarin A is a natural product that could be derived from sponge Dendrilla nigra. 7-Hydroxyneolamellarin A is a potent hypoxia-inducible factor-1α (HIF-1α) inhibitor. 7-Hydroxyneolamellarin A attenuates the accumulation of hypoxia-inducible factor-1α (HIF-1α) protein and inhibits vascular epidermal growth factor (VEGF) transcriptional activity. 7-Hydroxyneolamellarin A can be used in research of cancer .

HY-W647305

4-(5-(3-Hydroxypropyl)-7-methoxybenzofuran-2-yl)-2-methoxyphenol	Others	Others
4-(5-(3-Hydroxypropyl)-7-methoxybenzofuran-2-yl)-2-methoxyphenol is a Lignans product that can be isolated from the herbs of Diospyros lotus .

HY-133593

Palustric acid	Others	Others
Palustric acid is a diterpenic resin acid found in Pinus nigra .

HY-N12157

Noratherosperminine	Others	Others
Noratherosperminine is an alkaloid that can be isolated from the stem bark of Cryptocarya nigra .

HY-N8994

3-Hydroxy-4',5-dimethoxystilbene	Others	Cancer
3-Hydroxy-4',5-dimethoxystilbene is a natural compound found in stem bark of Morus nigra L .

HY-N11471

Steppogenin-7,4'-di-O-β-D-glucoside	Others	Others
Steppogenin-7,4'-di-O-β-D-glucoside is a natural product that can be isolated from the roots of Morus nigra .

HY-N11476

5,7-Dihydroxycoumarin 7-O-β-D-glucopyranoside	Others	Others
5,7-Dihydroxycoumarin 7-O-β-D-glucopyranoside is a natural product that can be isolated from the roots of Morus nigra .

HY-N3516

Oxyresveratrol 2-O-β-D-glucopyranoside	Tyrosinase	Metabolic Disease
Oxyresveratrol 2-O-β-D-glucopyranoside is a phenolic compound isolated from Morus nigra root and is an effective tyrosinase inhibitor with an IC₅₀ of 29.75 μM .

HY-N3517

Oxyresveratrol 3'-O-β-D-glucopyranoside	Tyrosinase	Metabolic Disease
Oxyresveratrol 3'-O-β-D-glucopyranoside is a phenolic compound isolated from Morus nigra root and is an effective tyrosinase inhibitor with an IC₅₀ of 1.64 μM .

HY-B0451

Dopamine 5+ Cited Publications ASL279 free base	Dopamine Receptor Endogenous Metabolite Ferroptosis	Neurological Disease
Dopamine is a catecholamine neurotransmitter that is produced in the substantia nigra, ventral tegmental area, and hypothalamus of the brain. Dopamine plays several important roles in the brain and body . Dopamine acts through D2 dopamine receptors to induce endocytosis of VEGFR2, which is critical for promoting angiogenesis .

HY-B0451A

Dopamine hydrochloride 5+ Cited Publications ASL279	Dopamine Receptor Endogenous Metabolite Ferroptosis	Neurological Disease
Dopamine hydrochloride (ASL279) is a catecholamine neurotransmitter that is produced in the substantia nigra, ventral tegmental area, and hypothalamus of the brain. Dopamine hydrochloride (ASL279) plays several important roles in the brain and body . Dopamine hydrochloride (ASL279) acts through D2 dopamine receptors to induce endocytosis of VEGFR2, which is critical for promoting angiogenesis .

HY-W008719

MPP+ iodide Maximum Cited Publications 11 Publications Verification	Mitochondrial Metabolism	Neurological Disease
MPP+ iodide, a toxic metabolite of the neurotoxin MPTP, causes symptom of Parkinson's disease in animal models by selectively destroying dopaminergic neurons in substantia nigra. MPP+ iodide is taken up by the dopamine transporter into dopaminergic neurons where it exerts its neurotoxic action on mitochondria by affecting complex I of the respiratory chain. MPP+ iodide is also a high affinity substrate for the serotonin transporter (SERT) .

HY-B0451AS7

Dopamine-d5 hydrochloride	Isotope-Labeled Compounds Dopamine Receptor Endogenous Metabolite Ferroptosis	Neurological Disease
Dopamine-d₅ (hydrochloride) is the deuterium labeled Dopamine (hydrochloride). Dopamine hydrochloride (ASL279) is a catecholamine neurotransmitter that is produced in the substantia nigra, ventral tegmental area, and hypothalamus of the brain. Dopamine hydrochloride (ASL279) plays several important roles in the brain and body[1]. Dopamine hydrochloride (ASL279) acts through D2 dopamine receptors to induce endocytosis of VEGFR2, which is critical for promoting angiogenesis[1].

HY-W008719S

MPP+-d3(iodide)	Mitochondrial Metabolism	Neurological Disease
MPP+-d₃ (iodide) is deuterium labeled MPP+ (iodide). MPP+ iodide, a toxic metabolite of the neurotoxin MPTP, causes symptom of Parkinson's disease in animal models by selectively destroying dopaminergic neurons in substantia nigra. MPP+ iodide is taken up by the dopamine transporter into dopaminergic neurons where it exerts its neurotoxic action on mitochondria by affecting complex I of the respiratory chain. MPP+ iodide is also a high affinity substrate for the serotonin transporter (SERT)[1][2].

HY-120475

PBT434 ATH434	α-synuclein	Neurological Disease
PBT434 is a potent, orally active and cross the blood-brain barrier α-synuclein aggregation inhibitor. PBT434 can be used as a iron chelator and modulates transcellular iron trafficking. PBT434 inhibits iron-mediated redox activity and iron-mediated aggregation of α-synuclein. PBT434 prevents the loss of substantia nigra pars compacta neurons (SNpc). PBT434 has the potential for the research of Parkinson’s disease (PD) .

HY-120475A

PBT434 mesylate ATH434 mesylate	α-synuclein	Neurological Disease
PBT434 methanesulfonate is a potent, orally active and cross the blood-brain barrier α-synuclein aggregation inhibitor. PBT434 methanesulfonate can be used as a iron chelator and modulates transcellular iron trafficking. PBT434 methanesulfonate inhibits iron-mediated redox activity and iron-mediated aggregation of α-synuclein. PBT434 methanesulfonate prevents the loss of substantia nigra pars compacta neurons (SNpc). PBT434 methanesulfonate has the potential for the research of Parkinson’s disease (PD) .

HY-163987

SIRT3 activator 2	Sirtuin	Neurological Disease
SIRT3 activator 2 (compound 2a) is a SIRT3 activator. SIRT3 activator 2 improved the thermal stability of SIRT3 in SH-SY5Y cells, indicating that it can directly bind to SIRT3, has SIRT3 dependency in SH-SY5Y to clear α-Syn. SIRT3 activator 2 improves motor function in Parkinson mice, preventing Parkinson (DA) neuron loss in the substantia nigra in a dose-dependent manner .

HY-160959

AN317	nAChR	Neurological Disease
AN317 is a selective agonist for α6β2-containing nicotinic acetylcholine receptor (nAChR) with K_i of 6.2 nM and 4.1 nM, for α6/α3β2β3 receptor and α4β2 receptor, respectively. AN317 induces dopamine release in the synaptosomes of the rat striatum, enhances dopaminergic neuronal activity in substantia nigra, and exhibits protective efficacy to rat neurons against dopamine neurotoxin MPP ⁺. AN317 exhibits good pharmacokinetic characteristics in rats. AN317 penetrates the blood-brain barrier (BB) .

HY-100539

PD 128907	Others	Others
PD 128907 is a D3 receptor ligand with activities of activating dopamine receptors, inhibiting cell firing, and inhibiting dopamine release. The active (+) enantiomer of PD 128907 has high affinity and selectivity for rat D3 dopamine receptors. PD 128907 inhibits cell firing in the ventral tegmental area and substantia nigra pars compacta with EC₅₀ values of 33nM and 38nM, respectively. PD 128907 also inhibits dopamine release in the caudate putamen with an EC₅₀ of 66nM. However, the selective D2 receptor antagonist L-741,626 has high affinity for receptors activated by PD 128907, indicating that the effects of PD 128907 are more likely on D2 autoreceptors rather than D3 dopamine receptor subtypes.

Cat. No.	Product Name

HY-L085

Anti-Parkinson's Disease Compound Library	1,466 compounds
Parkinson’s disease (PD), the second most common age-associated neurodegenerative disorder, is characterized by the loss of dopaminergic (DA) neurons and the presence of α-synuclein-containing aggregates in the substantia nigra pars compacta (SNpc). Motor features such as tremor, rigidity, bradykinesia and postural instability are common traits of PD. To date, there is no treatment to stop or at least slow down the progression of the disease. The etiology and pathogenesis of PD is still elusive, however, a large body of evidence suggests a prominent role of oxidative stress, inflammation, apoptosis, mitochondrial dysfunction and proteasome dysfunction in the pathogenesis of PD. MCE offers a unique collection of 1,466 compounds with anti- Parkinson’s Disease activities or targeting the unique targets of PD. MCE Anti- Parkinson's Disease Compound Library is a useful tool for exploring the mechanism of PD and discovering new drugs for PD.

Anti-Parkinson's Disease Compound Library

1,466 compounds

Parkinson’s disease (PD), the second most common age-associated neurodegenerative disorder, is characterized by the loss of dopaminergic (DA) neurons and the presence of α-synuclein-containing aggregates in the substantia nigra pars compacta (SNpc). Motor features such as tremor, rigidity, bradykinesia and postural instability are common traits of PD. To date, there is no treatment to stop or at least slow down the progression of the disease. The etiology and pathogenesis of PD is still elusive, however, a large body of evidence suggests a prominent role of oxidative stress, inflammation, apoptosis, mitochondrial dysfunction and proteasome dysfunction in the pathogenesis of PD.

MCE offers a unique collection of 1,466 compounds with anti- Parkinson’s Disease activities or targeting the unique targets of PD. MCE Anti- Parkinson's Disease Compound Library is a useful tool for exploring the mechanism of PD and discovering new drugs for PD.

Cat. No.	Product Name	Type

HY-NP080

*Sambucus Nigra* Lectin** SNA	Native Proteins
Sambucus Nigra Lectin (SNA) is a plant lectin that can be used as a probe to specifically bind biomolecules (such as polysaccharides, peptides, etc.).Sambucus Nigra Lectin (SNA) is a biological material or organic compound that can be used in life science research .

HY-NP0166

*Sambucus Nigra* Lectin (Agarose)**	Native Proteins
Sambucus Nigra Lectin (Agarose) is a plant lectin that can be used as a probe to specifically bind biomolecules (such as polysaccharides, peptides, etc.).Sambucus Nigra Lectin (Agarose) is a biological material or organic compound that can be used in life science research .

HY-NP0142

*Sambucus Nigra* Lectin (Fluorescein)** SNA (Fluorescein)	Native Proteins
Sambucus Nigra Lectin (SNA) Fluorescein is a plant lectin that can be used as a probe to specifically bind biomolecules (such as polysaccharides, peptides, etc.).Sambucus Nigra Lectin (SNA) Fluorescein is a biological material or organic compound that can be used in life science research .

HY-NP0149

*Sambucus Nigra* Lectin (Biotinylated)** SNA (Biotinylated)	Native Proteins
Sambucus Nigra Lectin (SNA) Biotinylated is a plant lectin that can be used as a probe to specifically bind biomolecules (such as polysaccharides, peptides, etc.).Sambucus Nigra Lectin (SNA) Biotinylated is a biological material or organic compound that can be used in life science research .

HY-NP092

*Sambucus Nigra* Lectin (CY3)** SNA (CY3)	Native Proteins
Sambucus Nigra Lectin (SNA) CY3 is a plant lectin that can be used as a probe to specifically bind biomolecules (such as polysaccharides, peptides, etc.).Sambucus Nigra Lectin (SNA) CY3 is a biological material or organic compound that can be used in life science research .

HY-NP094

*Sambucus Nigra* Lectin (CY5)** SNA (CY5)	Native Proteins
Sambucus Nigra Lectin (SNA) CY5 is a plant lectin that can be used as a probe to specifically bind biomolecules (such as polysaccharides, peptides, etc.).Sambucus Nigra Lectin (SNA) CY5 is a biological material or organic compound that can be used in life science research .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-121227

Cylindrin	Triterpenes Structural Classification Terpenoids Ebenaceae Diospyros nigra (J.F.Gmel.) M.R.Almeida Source classification Plants	Others
Cylindrin is a natural product that can be found in Diospyros nigra .

HY-N12541

Morunigrol C	Structural Classification Source classification Morus nigra Linn. Phenols Polyphenols Plants Moraceae	Others
Morunigrol C is a compound that can be isolated from the barks of Morus nigra .

HY-N12810

Sanggenon O	Structural Classification Source classification Morus nigra Linn. Phenols Polyphenols Plants Moraceae	Tyrosinase
Sanggenon O is a mushroom tyrosinase inhibitor that can be isolated from Morus nigra, with an IC₅₀ value of 1.15 μM .

HY-N10330

7-Hydroxyneolamellarin A	Structural Classification Animals Source classification Phenols	HIF/HIF Prolyl-Hydroxylase VEGFR
7-Hydroxyneolamellarin A is a natural product that could be derived from sponge Dendrilla nigra. 7-Hydroxyneolamellarin A is a potent hypoxia-inducible factor-1α (HIF-1α) inhibitor. 7-Hydroxyneolamellarin A attenuates the accumulation of hypoxia-inducible factor-1α (HIF-1α) protein and inhibits vascular epidermal growth factor (VEGF) transcriptional activity. 7-Hydroxyneolamellarin A can be used in research of cancer .

HY-W647305

4-(5-(3-Hydroxypropyl)-7-methoxybenzofuran-2-yl)-2-methoxyphenol	Structural Classification Ebenaceae Source classification Lignans Phenylpropanoids Plants Diospyros lotus L.	Others
4-(5-(3-Hydroxypropyl)-7-methoxybenzofuran-2-yl)-2-methoxyphenol is a Lignans product that can be isolated from the herbs of Diospyros lotus .

HY-133593

Palustric acid	Structural Classification other families Classification of Application Fields Ketones, Aldehydes, Acids Source classification Other Diseases Plants Disease Research Fields	Others
Palustric acid is a diterpenic resin acid found in Pinus nigra .

HY-N12157

Noratherosperminine	Structural Classification Alkaloids Other Alkaloids Source classification Plants Lauraceae Cryptocarya nigra Kosterm.	Others
Noratherosperminine is an alkaloid that can be isolated from the stem bark of Cryptocarya nigra .

HY-N8994

3-Hydroxy-4',5-dimethoxystilbene	Monophenols Stilbenes Classification of Application Fields Source classification Morus nigra Linn. Phenols Plants Moraceae Disease Research Fields Cancer	Others
3-Hydroxy-4',5-dimethoxystilbene is a natural compound found in stem bark of Morus nigra L .

HY-N11471

Steppogenin-7,4'-di-O-β-D-glucoside	Structural Classification Flavonoids Flavonones Source classification Morus nigra Linn. Plants Moraceae	Others
Steppogenin-7,4'-di-O-β-D-glucoside is a natural product that can be isolated from the roots of Morus nigra .

HY-N11476

5,7-Dihydroxycoumarin 7-O-β-D-glucopyranoside	Structural Classification Natural Products Source classification Morus nigra Linn. Plants Moraceae	Others
5,7-Dihydroxycoumarin 7-O-β-D-glucopyranoside is a natural product that can be isolated from the roots of Morus nigra .

HY-N3516

Oxyresveratrol 2-O-β-D-glucopyranoside	Stilbenes Classification of Application Fields Source classification Phenols Polyphenols Metabolic Disease Plants Moraceae Disease Research Fields Morus alba Linn.	Tyrosinase
Oxyresveratrol 2-O-β-D-glucopyranoside is a phenolic compound isolated from Morus nigra root and is an effective tyrosinase inhibitor with an IC₅₀ of 29.75 μM .

HY-N3517

Oxyresveratrol 3'-O-β-D-glucopyranoside	Structural Classification Classification of Application Fields Polygonaceae Whitening Agent Source classification Reynoutria japonica Houtt. Metabolic Disease Plants Stilbenes Phenols Polyphenols Cosmetic Research Disease Research Fields	Tyrosinase
Oxyresveratrol 3'-O-β-D-glucopyranoside is a phenolic compound isolated from Morus nigra root and is an effective tyrosinase inhibitor with an IC₅₀ of 1.64 μM .

HY-B0451

Dopamine 5+ Cited Publications ASL279 free base	Structural Classification Phenols Polyphenols Endogenous metabolite	Dopamine Receptor Endogenous Metabolite Ferroptosis
Dopamine is a catecholamine neurotransmitter that is produced in the substantia nigra, ventral tegmental area, and hypothalamus of the brain. Dopamine plays several important roles in the brain and body . Dopamine acts through D2 dopamine receptors to induce endocytosis of VEGFR2, which is critical for promoting angiogenesis .

HY-B0451A

Dopamine hydrochloride 5+ Cited Publications ASL279	Structural Classification Microorganisms Source classification Phenols Polyphenols Endogenous metabolite	Dopamine Receptor Endogenous Metabolite Ferroptosis
Dopamine hydrochloride (ASL279) is a catecholamine neurotransmitter that is produced in the substantia nigra, ventral tegmental area, and hypothalamus of the brain. Dopamine hydrochloride (ASL279) plays several important roles in the brain and body . Dopamine hydrochloride (ASL279) acts through D2 dopamine receptors to induce endocytosis of VEGFR2, which is critical for promoting angiogenesis .

Cat. No.	Product Name	Chemical Structure

HY-B0451AS7

Dopamine-d5 hydrochloride

Dopamine-d₅ (hydrochloride) is the deuterium labeled Dopamine (hydrochloride). Dopamine hydrochloride (ASL279) is a catecholamine neurotransmitter that is produced in the substantia nigra, ventral tegmental area, and hypothalamus of the brain. Dopamine hydrochloride (ASL279) plays several important roles in the brain and body[1]. Dopamine hydrochloride (ASL279) acts through D2 dopamine receptors to induce endocytosis of VEGFR2, which is critical for promoting angiogenesis[1].

HY-W008719S

MPP+-d3(iodide)

MPP+-d₃ (iodide) is deuterium labeled MPP+ (iodide). MPP+ iodide, a toxic metabolite of the neurotoxin MPTP, causes symptom of Parkinson's disease in animal models by selectively destroying dopaminergic neurons in substantia nigra. MPP+ iodide is taken up by the dopamine transporter into dopaminergic neurons where it exerts its neurotoxic action on mitochondria by affecting complex I of the respiratory chain. MPP+ iodide is also a high affinity substrate for the serotonin transporter (SERT)[1][2].

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<i>Diospyros nigra<_i> (J.F.Gmel.) M.R.Almeida

Inhibitors & Agonists

Screening Libraries

Biochemical Assay Reagents

NaturalProducts

Isotope-Labeled Compounds

Natural
Products